This is the event that begins it all. Jesus attends a wedding at Cana, likely for a relative, and performs the first of His signs. That vocabulary is important. This isn’t His first miracle. There have been plenty of those, and we just celebrated them in December. Jesus was incarnate by the Holy Spirit of the Virgin Mary—a miracle. Aged Zacharias and Elizabeth had a son—a miracle. The wise men were led to the little Boy by a star—a miracle. Even in Jesus’ adulthood He was already performing miracles when He called His first disciples. Though He was nowhere near, He saw Nathaniel under the fig tree. So, while water being changed into wine is certainly a miracle, it is not Jesus’ first.
As Jesus begins His public ministry, He begins it by teaching us to rely on Him for all things, and above all, to remember that the things of this life are secondary to the greatest thing He has come to give, which is our salvation.